[av_section min_height=” min_height_pc=’25’ min_height_px=’200px’ shadow=’no-border-styling’ bottom_border=’no-border-styling’ bottom_border_diagonal_color=’#333333′ bottom_border_diagonal_direction=” bottom_border_style=” padding=’no-padding’ custom_margin=’0px’ custom_margin_sync=’true’ svg_div_top=” svg_div_top_color=’#333333′ svg_div_top_width=’100′ svg_div_top_height=’50’ svg_div_top_max_height=’none’ svg_div_top_opacity=” svg_div_bottom=” svg_div_bottom_color=’#333333′ svg_div_bottom_width=’100′ svg_div_bottom_height=’50’ svg_div_bottom_max_height=’none’ svg_div_bottom_opacity=” color=’main_color’ background=’bg_color’ custom_bg=” background_gradient_direction=’vertical’ background_gradient_color1=’#000000′ background_gradient_color2=’#ffffff’ background_gradient_color3=” src=’https://gyldenpharma.com/wp-content/uploads/2022/05/BAnner-1.jpg’ attachment=’1475′ attachment_size=’full’ attach=’scroll’ position=’center center’ repeat=’stretch’ video=” video_ratio=’16:9′ overlay_opacity=’0.5′ overlay_color=” overlay_pattern=” overlay_custom_pattern=” custom_arrow_bg=” css_position_z_index=” av-medium-css_position_z_index=” av-small-css_position_z_index=” av-mini-css_position_z_index=” id=’bannerjude’ custom_class=” template_class=” aria_label=” av_element_hidden_in_editor=’0′ av_uid=’av-1h5x4xc’ sc_version=’1.0′][/av_section]

Technology

Gylden are developing an extensive range of T cell-priming vaccines and immunotherapy candidates for infectious diseases and other indications using core proprietary technologies designed to elicit broad and long-lasting cellular immune responses.

[/av_textblock]
[/av_section]

[av_textblock textblock_styling_align=” textblock_styling=” textblock_styling_gap=” textblock_styling_mobile=” size=” av-desktop-font-size=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” font_color=” color=” id=” custom_class=” template_class=” av_uid=’av-1rhws0′ sc_version=’1.0′ admin_preview_bg=”]

Gylden product candidates are comprised of the core technologies described below:

[/av_textblock]

[av_textblock textblock_styling_align=” textblock_styling=” textblock_styling_gap=” textblock_styling_mobile=” size=’18’ av-desktop-font-size=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” font_color=” color=” id=” custom_class=” template_class=” av_uid=’av-l50w4mq9′ sc_version=’1.0′ admin_preview_bg=”]

Immunoproteomics and Multi-Omic Technologies
- An MHC Class I expression ‘ligandome library’ of pathogen-derived protein fragments (peptides) are experimentally-determined to be expressed on the surface of pathogen-infected cells and therefore represent the targets of the T cell response during an infection.

Nanotechnology Particles: An ultrasmall carbohydrate-passivated nanocluster delivery system
- Fully synthetic peptides are designed to be efficiently delivered to the skin-resident immune system to elicit a robust T cell immune response.

Microneedle Array Patch [MAP] Technology
- Advanced delivery and R&D assets were acquired via the purchase of Zosano Pharma in 2022. Preliminary studies were completed that combine Zosano MAP technology with our T cell-priming candidates, consolidating the platform’s potential and supporting the development of our many other T cell-priming candidates.

In-house GMP Nanomedicine Manufacturing Capabilities
- Issued by the UK’s MHRA, the Company received its MIA(IMP) license and cGMP accreditation in 2024.

[/av_textblock]

[av_section min_height=” min_height_px=’500px’ padding=’default’ shadow=’no-border-styling’ bottom_border=’no-border-styling’ bottom_border_diagonal_color=’#333333′ bottom_border_diagonal_direction=” bottom_border_style=” custom_arrow_bg=” id=” color=’alternate_color’ custom_bg=” src=” attachment=” attachment_size=” attach=’scroll’ position=’top left’ repeat=’no-repeat’ video=” video_ratio=’16:9′ overlay_opacity=’0.5′ overlay_color=” overlay_pattern=” overlay_custom_pattern=” av_element_hidden_in_editor=’0′ custom_class=” av_uid=’av-1g4a428′]
[av_one_half first min_height=’av-equal-height-column’ vertical_alignment=’av-align-top’ space=’no_margin’ row_boxshadow_color=” row_boxshadow_width=’10’ margin=’0px’ margin_sync=’true’ mobile_breaking=” mobile_column_order=” min_col_height=” padding=’20px,,,’ svg_div_top=” svg_div_top_color=’#333333′ svg_div_top_width=’100′ svg_div_top_height=’50’ svg_div_top_max_height=’none’ svg_div_top_opacity=” svg_div_bottom=” svg_div_bottom_color=’#333333′ svg_div_bottom_width=’100′ svg_div_bottom_height=’50’ svg_div_bottom_max_height=’none’ svg_div_bottom_opacity=” border=” border_style=’solid’ border_color=” radius=” radius_sync=’true’ column_boxshadow_color=” column_boxshadow_width=’10’ background=’bg_color’ background_color=” background_gradient_direction=’vertical’ background_gradient_color1=’#000000′ background_gradient_color2=’#ffffff’ background_gradient_color3=” src=” attachment=” attachment_size=” background_position=’center center’ background_repeat=’stretch’ highlight_size=’1.1′ animation=” link=” linktarget=” link_hover=” title_attr=” alt_attr=” mobile_display=” mobile_col_pos=’0′ id=” custom_class=” template_class=” aria_label=” av_uid=’av-4t6du8′ sc_version=’1.0′]

[av_textblock textblock_styling_align=” textblock_styling=” textblock_styling_gap=” textblock_styling_mobile=” size=” av-desktop-font-size=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” font_color=” color=” id=” custom_class=” template_class=” av_uid=’av-l4zkoh8f’ sc_version=’1.0′ admin_preview_bg=”]
With Gylden’s product candidates, viral peptides are presented to T cells as in the natural immune response.

Gylden’s approach is designed to deliver fully synthetic viral peptides to antigen presenting cells (eg. dendritic cells ), activating naïve T cells with specificity to a virus that are then expanded to a memory phenotype.
Such virus-specific memory CD8+ T cells have the potential to migrate to tissue sites of potential pathogen exposure following a second vaccination.
A pre-existing population of virus-specific CD8+ T cells is thus created that, upon subsequent pathogen encounter, would be able to immediately kill infected cells before they can release virions, and the infection is rapidly terminated.

[/av_textblock]

[/av_one_half][av_one_half min_height=” vertical_alignment=’av-align-top’ space=” row_boxshadow=” row_boxshadow_color=” row_boxshadow_width=’10’ custom_margin=” margin=’0px’ mobile_breaking=” mobile_column_order=” min_col_height=” padding=” svg_div_top=” svg_div_top_color=’#333333′ svg_div_top_width=’100′ svg_div_top_height=’50’ svg_div_top_max_height=’none’ svg_div_top_flip=” svg_div_top_invert=” svg_div_top_front=” svg_div_top_opacity=” svg_div_top_preview=” svg_div_bottom=” svg_div_bottom_color=’#333333′ svg_div_bottom_width=’100′ svg_div_bottom_height=’50’ svg_div_bottom_max_height=’none’ svg_div_bottom_flip=” svg_div_bottom_invert=” svg_div_bottom_front=” svg_div_bottom_opacity=” svg_div_bottom_preview=” border=” border_style=’solid’ border_color=” radius=” column_boxshadow=” column_boxshadow_color=” column_boxshadow_width=’10’ background=’bg_color’ background_color=” background_gradient_direction=’vertical’ background_gradient_color1=’#000000′ background_gradient_color2=’#ffffff’ background_gradient_color3=” src=” background_position=’top left’ background_repeat=’no-repeat’ highlight=” highlight_size=” animation=” link=” linktarget=” link_hover=” title_attr=” alt_attr=” mobile_display=” mobile_col_pos=’0′ id=” custom_class=” template_class=” aria_label=” av_uid=’av-hsbxxs’ sc_version=’1.0′]

[av_slideshow size=’featured_large’ control_layout=’av-control-default’ conditional_play=” animation=’slide’ transition_speed=” autoplay=’false’ interval=’5′ img_scrset=” lazy_loading=’enabled’ alb_description=” id=” custom_class=’judecaption’ template_class=” av_uid=’av-g5allc’ sc_version=’1.0′]
[av_slide slide_type=’image’ id=’1587′ video=’https://’ mobile_image=” fallback_link=’https://’ title=’Dendritic cell activation. ‘ video_ratio=’16:9′ av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” heading_tag=” heading_class=” link_apply=” link=’lightbox’ link_target=” av_uid=’av-bchj9c’ sc_version=’1.0′ video_autoplay=” video_controls=” video_mute=” video_loop=”][/av_slide]
[av_slide slide_type=’image’ id=’1589′ video=’https://’ mobile_image=” fallback_link=’https://’ title=’Activation of T-cell by activated dendritic cell.’ video_ratio=’16:9′ av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” heading_tag=” heading_class=” link_apply=” link=’lightbox’ link_target=” av_uid=’av-eeh5k0′ sc_version=’1.0′ video_autoplay=” video_controls=” video_mute=” video_loop=”][/av_slide]
[av_slide slide_type=’image’ id=’1588′ video=’https://’ mobile_image=” fallback_link=’https://’ title=’ Infected cell death by T cell.’ video_ratio=’16:9′ av-medium-font-size-title=” av-small-font-size-title=” av-mini-font-size-title=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” heading_tag=” heading_class=” link_apply=” link=’lightbox’ link_target=” av_uid=’av-c69f80′ sc_version=’1.0′ video_autoplay=” video_controls=” video_mute=” video_loop=”][/av_slide]
[/av_slideshow]

[/av_one_half]
[/av_section]

[av_one_full first min_height=” vertical_alignment=’av-align-top’ space=” row_boxshadow=” row_boxshadow_width=’10’ row_boxshadow_color=” custom_margin=” margin=’0px’ mobile_breaking=” mobile_column_order=” border=” border_style=’solid’ border_color=” radius=” min_col_height=” padding=” svg_div_top=” svg_div_top_color=’#333333′ svg_div_top_width=’100′ svg_div_top_height=’50’ svg_div_top_max_height=’none’ svg_div_top_flip=” svg_div_top_invert=” svg_div_top_front=” svg_div_top_opacity=” svg_div_top_preview=” svg_div_bottom=” svg_div_bottom_color=’#333333′ svg_div_bottom_width=’100′ svg_div_bottom_height=’50’ svg_div_bottom_max_height=’none’ svg_div_bottom_flip=” svg_div_bottom_invert=” svg_div_bottom_front=” svg_div_bottom_opacity=” svg_div_bottom_preview=” column_boxshadow=” column_boxshadow_width=’10’ column_boxshadow_color=” background=’bg_color’ background_color=” background_gradient_direction=’vertical’ background_gradient_color1=’#000000′ background_gradient_color2=’#ffffff’ background_gradient_color3=” src=” background_position=’top left’ background_repeat=’no-repeat’ highlight=” highlight_size=” animation=” animation_duration=” animation_custom_bg_color=” animation_z_index_curtain=’100′ parallax_parallax=” parallax_parallax_speed=” av-medium-parallax_parallax=” av-medium-parallax_parallax_speed=” av-small-parallax_parallax=” av-small-parallax_parallax_speed=” av-mini-parallax_parallax=” av-mini-parallax_parallax_speed=” css_position=” css_position_location=” css_position_z_index=” av-medium-css_position=” av-medium-css_position_location=” av-medium-css_position_z_index=” av-small-css_position=” av-small-css_position_location=” av-small-css_position_z_index=” av-mini-css_position=” av-mini-css_position_location=” av-mini-css_position_z_index=” link=” linktarget=” link_hover=” title_attr=” alt_attr=” mobile_display=” mobile_col_pos=’0′ id=” custom_class=” template_class=” aria_label=” av_uid=’av-22qkog’ sc_version=’1.0′]
[av_textblock textblock_styling_align=” textblock_styling=” textblock_styling_gap=” textblock_styling_mobile=” size=” av-desktop-font-size=” av-medium-font-size=” av-small-font-size=” av-mini-font-size=” font_color=” color=” id=” custom_class=” template_class=” av_uid=’av-l4zk5y5f’ sc_version=’1.0′ admin_preview_bg=”]

An approach designed to mimic natural immunity

Our goal is to create a critical mass of ‘primed’ tissue-resident memory CD8+ T cells and shorter-lived CD8+ T effector cells with specificities to early pathogen peptides, equipped to provide broad and long-lasting cellular immunity upon subsequent infection. T cell adaptive vaccines evoke the course of cellular immunity that is prompted through natural infection but halt the infection locally — at the site of transmission — before progression to full-blown disease would take place.

Product candidates designed to prime the immune system to enable a rapid response to future infection

The adaptive immune response to an infection includes CD8+ T cells that recognize pathogen-derived peptides (below, from a viral infection) associated with MHC Class I molecules expressed on the surface of infected cells.
[/av_textblock]
[/av_one_full]

[av_one_full first min_height=’av-equal-height-column’ vertical_alignment=’av-align-top’ space=” margin=’0px’ margin_sync=’true’ padding=” padding_sync=’true’ border=” border_color=” radius=” radius_sync=’true’ background_color=’#ffffff’ src=” attachment=” attachment_size=” background_position=’center center’ background_repeat=’stretch’ animation=” mobile_breaking=” mobile_display=” custom_class=” av_uid=’av-1k44vk’]
[av_image src=’https://gyldenpharma.com/wp-content/uploads/2022/10/emergex45.png’ attachment=’1810′ attachment_size=’full’ copyright=” caption=” image_size=’2048×2048′ styling=” box_shadow=’none’ box_shadow_width=’10’ box_shadow_color=” align=’center’ font_size=” overlay_opacity=’0.4′ overlay_color=’#000000′ overlay_text_color=’#ffffff’ animation=’no-animation’ animation_duration=” animation_custom_bg_color=” animation_z_index_curtain=’100′ parallax_parallax=” parallax_parallax_speed=” av-desktop-parallax_parallax=” av-desktop-parallax_parallax_speed=” av-medium-parallax_parallax=” av-medium-parallax_parallax_speed=” av-small-parallax_parallax=” av-small-parallax_parallax_speed=” av-mini-parallax_parallax=” av-mini-parallax_parallax_speed=” hover=” blur_image=” grayscale_image=” fade_image=” appearance=” css_position=” css_position_location=’,,,’ css_position_z_index=” av-desktop-css_position=” av-desktop-css_position_location=’,,,’ av-desktop-css_position_z_index=” av-medium-css_position=” av-medium-css_position_location=’,,,’ av-medium-css_position_z_index=” av-small-css_position=” av-small-css_position_location=’,,,’ av-small-css_position_z_index=” av-mini-css_position=” av-mini-css_position_location=’,,,’ av-mini-css_position_z_index=” transform_perspective=” transform_rotation=’,,,’ transform_scale=’,,’ transform_skew=’,’ transform_translate=’,,’ av-desktop-transform_perspective=” av-desktop-transform_rotation=’,,,’ av-desktop-transform_scale=’,,’ av-desktop-transform_skew=’,’ av-desktop-transform_translate=’,,’ av-medium-transform_perspective=” av-medium-transform_rotation=’,,,’ av-medium-transform_scale=’,,’ av-medium-transform_skew=’,’ av-medium-transform_translate=’,,’ av-small-transform_perspective=” av-small-transform_rotation=’,,,’ av-small-transform_scale=’,,’ av-small-transform_skew=’,’ av-small-transform_translate=’,,’ av-mini-transform_perspective=” av-mini-transform_rotation=’,,,’ av-mini-transform_scale=’,,’ av-mini-transform_skew=’,’ av-mini-transform_translate=’,,’ mask_overlay=” mask_overlay_shape=’blob’ mask_overlay_size=’contain’ mask_overlay_scale=’100%’ mask_overlay_position=’center center’ mask_overlay_repeat=’no-repeat’ mask_overlay_rotate=” mask_overlay_rad_shape=’circle’ mask_overlay_rad_position=’center center’ mask_overlay_opacity1=’0′ mask_overlay_opacity2=’1′ mask_overlay_opacity3=” link=” target=” title_attr=” alt_attr=” img_scrset=” lazy_loading=’disabled’ id=” custom_class=” template_class=” av_element_hidden_in_editor=’0′ av_uid=’av-4fhuo’ sc_version=’1.0′ admin_preview_bg=”][/av_image]
[/av_one_full]

[av_one_full first min_height=’av-equal-height-column’ vertical_alignment=’av-align-top’ space=’no_margin’ margin=’0px’ margin_sync=’true’ padding=” padding_sync=’true’ border=” border_color=” radius=” radius_sync=’true’ background_color=’#ffffff’ src=” attachment=” attachment_size=” background_position=’center center’ background_repeat=’stretch’ animation=” mobile_breaking=” mobile_display=” custom_class=” av_uid=’av-b777eo’]
[av_buttonrow alignment=’center’ button_spacing=’5′ button_spacing_unit=’px’ alb_description=” id=” custom_class=” template_class=” av_uid=’av-617tgg’ sc_version=’1.0′ admin_preview_bg=”]
[av_buttonrow_item label=’Vaccine Advantages’ icon_select=’no’ icon=’5′ font=’entypo-fontello’ link=’page,107′ link_target=” size=’small’ label_display=” title_attr=” color_options=” color=’theme-color’ custom_bg=’#444444′ custom_font=’#ffffff’ btn_color_bg=’theme-color’ btn_custom_grad_direction=’vertical’ btn_custom_grad_1=’#000000′ btn_custom_grad_2=’#ffffff’ btn_custom_grad_3=” btn_custom_grad_opacity=’0.7′ btn_custom_bg=’#444444′ btn_color_bg_hover=’theme-color-highlight’ btn_custom_bg_hover=’#444444′ btn_color_font=’theme-color’ btn_custom_font=’#ffffff’ btn_color_font_hover=’white’ btn_custom_font_hover=’#ffffff’ border=” border_width=” border_width_sync=’true’ border_color=” border_radius=” border_radius_sync=’true’ box_shadow=” box_shadow_style=’0px,0px,0px,0px’ box_shadow_color=” hover_opacity=” sonar_effect_effect=” sonar_effect_color=” sonar_effect_duration=’1′ sonar_effect_scale=” sonar_effect_opac=’0.5′ av_uid=’av-2lg0i8′ sc_version=’1.0′ icon_hover=”]
[/av_buttonrow]
[/av_one_full]